Collaborative preclinical study with Dr. Jason Yustein of Emory University funded by the Rutledge Cancer Foundation.
FT WORTH, TEXAS, May 5, 2023, — Rutledge Cancer Foundation (RCF) granted $100,000 to Jason Yustein’s lab at Emory University. Yustein and his colleagues are working to understand the molecular pathways of sarcomas and the identification of new therapeutic avenues to improve survival rates.
Sadly, research efforts over the past 40 years have done little to improve patient outcomes for sarcomas. The Yustein laboratory has tremendous experience in merging innovative murine models including novel, genetically engineered mouse models of pediatric sarcomas and patient-derived samples towards garnering molecular insights into the origins of Ewing sarcoma cells and their response and resistance to new therapies.
With this grant, Yustein’s lab will conduct a set of animal experiments to validate the potential efficacy of Myr5A, a targeted delivery lipid nanoparticle, in combination with two new therapies for Ewing sarcoma and DSRST. The goal is to develop targeted anti-tumor agents with excellent efficacy and significantly reduced toxicity.